RNA Details
Disease Name
pulmonary hypertension
Tissue
lung
RNA Symbol
mir-17
RNA ID
RNA Type
miRNA
Alteration Pattern
up regulation
Species
homo sapiens
Detection Methods
qRT-PCR; Quantification of Mature miR-20a; etc.
Target
BMPR2
Pathway
STAT3-miR-17/92-BMPR2 signaling pathway
PubMed ID
Title
Interleukin-6 modulates the expression of the bone morphogenic protein receptor type II through a novel STAT3-microRNA cluster 17/92 pathway
Year
2009
Function
"Ectopic overexpression of miR-17/92 resulted in a strong reduction of the BMPR2 protein, and a reporter gene system showed that BMPR2 is directly targeted by miR-17-5p and miR-20a. By stimulation experiments, we found that the miR-17/92 cluster is modulated by interleukin (IL)-6, a cytokine involved in the pathogenesis of pulmonary hypertension. "